One-Pot Multicomponent Synthesis and Bioevluation of New1H-Pyrazole-1-Carbothioamide Derivatives Promoted by Bronsted Acid

Several methods were developed for the synthesis of the most significant series 1H-pyrazole-1-carbothioamide derivatives in the current study. The advantages method process for preparing titled derivatives had several disadvantages, such as challenging workup, longer reaction times, high reagent costs, and the effects of organic solvents. These derivatives can be obtained by the reaction of hydrazine hydrate, substituted benzylidene malononitrile and isothiocyanates in the employed PTSA in aqueous medium at 90°C. The main benefits of the protocols include more yields of derivatives, a broad range of substrates, simple method of procedure, and low time of reaction. The confirmation of desired derivative is followed by advanced spectroscopic interpretation of 1HNMR, 13CNMR and LCMS. In addition to the study of antimicrobial activity derivatives against bacterial as well as fungal strains which are referred to standard drugs by streptomycin and Ketonozole.