Mechanisms of Effect of Arjunolic Acid on Cyclosporine A Induced Renal Tubular Cell Apoptosis |
Author(s): |
Dr.P.Vasanthi , Bharathi Womens College; Dr.C.S.Parameswari, Principal, Government Arts and Science College |
Keywords: |
Cyclosporine, Apoptosis, Arjunolic acid |
Abstract |
Apoptosis is an important pathogenic mechanism in renal diseases, during development and injury. Lethally injured cells may die by either necrosis or apoptosis, depending on the severity of the injury. Severe renal ischemia results in acute tubular necrosis, chronic low grade ischemia leads to apoptosis in renal tubular cells. Cyclosporine-induced apoptotic cell death is closely associated with activation of proapoptotic genes and altered regulation of apoptosis-regulating genes. Cyclosporine A (CsA) has considerably modified the graft survival in solid organ and bone marrow transplantation. Renal toxicity is the major adverse effect of chronic CsA administration. Deterioration of renal function and renal histopathology are the basic elements of the diagnosis. In the present study, the lethal pathways activated by cyclosporine A (CsA), a nephrotoxin that induces caspase-dependent apoptosis in tubular epithelium, were explored. The Tubular cell apoptosis is the major contributing factor to the pathogenesis of renal injury. The understanding of the CsA renal effects is not only a research interest, but also clinically important in developing a strategy in the prevention and treatment of the disease. In this contribution, we will discuss this effect and its significance for the mechanism of action of Bax, cytochrome c, caspase-3 in renal tubular cells, an important checkpoint of the apoptotic process. |
Other Details |
Paper ID: IJSRDV3I90283 Published in: Volume : 3, Issue : 9 Publication Date: 01/12/2015 Page(s): 487-491 |
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