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Structure and Function of Biomembrane Ion Channel


Prof. Ashwini Ganpat Kharde , P.Dr.V.V.Patil Polytechnic Loni; Prof. Prashant Sampat Kale, P.Dr.V.V.Patil Polytechnic Loni; Prof N. M. Garad, P.Dr.V.V.Patil Polytechnic Loni


Amino Acids, Viral, Prokaryotic, Eukaryotic, Enzymes, Molecular Transport


Conventional oxidation processes are used in water Viral ion channels are short auxiliary membrane proteins with a length of ca. 100 amino acids. They are found in enveloped viruses from influenza A, influenza B and influenza C (Orthomyxoviridae), and the human immunodeficiency virus type 1 (HIV-1, Retroviridae). The channels are called M2 (influenza A), NB (influenza B), CM2 (influenza C) and Vpu (HIV-1). Recently, in Paramecium bursaria chlorella virus (PBCV-1, Phycodnaviridae), a K. selective ion channel has been discovered. The viral channels form homo oligomers to allow an ion flux and represent miniaturised systems. Proton conductivity of M2 is established; NB, Vpu and the potassium channel from PBC-1 conduct ions; for CM2 ion conductivity is still under proof. This review summarises the current knowledge of these short viral membrane proteins. Their discovery is outlined and experimental evidence for their structure and function is discussed. Studies using computational methods are presented as well as investigations of drug protein interactions. Membranes play a central role in both the structure and function of all cells, prokaryotic and eukaryotic, plant and animal. Membranes basically define compartments, each membrane associated with an inside and an outside. If this were all they did, membranes would be considerably importance and Diversity of Membranes less interesting than they are. But, membranes not only define compartments, they also determine the nature of all communication between the inside and outside. This may take the form of actual passage of ions or molecules between the two compartments (in and out) or may be in the form of information, transmitted through conformational changes induced in membrane components. In addition, attached to membranes are many cellular enzymes. Some of these enzymes catalyze transmembrane reactions, involving reactants on both sides of the membrane or molecular transport. Others are involved in sequential reactions involving a series of enzymes which are concentrated in the plane of the membrane, thus facilitating efficient interactions. Still other enzymes have membrane-bound subs.

Other Details

Paper ID: IJSRDV7I70339
Published in: Volume : 7, Issue : 7
Publication Date: 01/10/2019
Page(s): 439-446

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