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Preliminary in Silico Studies on the Role of Nisin Cyclase in Food Preservation

Author(s):

Gunsheen Kaur , D S Kothari Centre, Miranda House, University of Delhi; Dr. Smriti Sharma Bhatia, D S Kothari Centre, Miranda House, University of Delhi

Keywords:

RMSD, Docking, Lantibiotic

Abstract

This paper presents computational studies that estimate the RMSD distances of Nisin in its Cyclase form. Nisin Cyclase, the Cyclase of lantibiotic Nisin is a kind of bacterial toxin produced by lactococcus lactic and is widely accepted as a safe biological preservative. This paper showcases computational studies as an effective tool to estimate the docking affinities for 416ZN as an integral part of Nisin Cyclase which owning to a large RMSD distance with its binding sites proves its efficiency as a food preservative and also opens pathways for creation of model food preservatives from grid data accomplished by computational studies. Docking protocol for the RMSD distance was carried out using 416ZN conformation. These are preliminary studies that indicate a sequence and more sophisticated investigations are required for detailed analysis.

Other Details

Paper ID: NCILP042
Published in: Conference 1 : NCIL 2015
Publication Date: 16/10/2015
Page(s): 170-171

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