Preparation and Comparison of Dissolution Profiles of Aceclofenac by Solid Dispersion Approach

Approximately 40% of new chemical entities suffer from poor aqueous solubility results into poor bioavailability lead to the major challenge to modern drug delivery system. Among various approaches used to enhance aqueous solubility of BCS Class-II drugs, one of these approaches is solid dispersion which is usually used to improve the bioavailability of most hydrophobic drugs. Aceclofenac is used as an analgesic and anti-inflammatory drug in the treatment of osteo arthritis, rheumatoid arthritis and spondylitis. Three different compositions of Aceclofenac solid dispersions were prepared by solvent evaporation method using Urea as a carrier in order to enhance the solubility of BCS Class-II drugs. Based on the in-vtiro drug release pattern of Aceclofenac: Urea with the ratio of 1:3 was considered as an ideal dispersion for the improvement of solubility, dissolution rate and bioavailability of poorly water soluble drug via solid dispersion.