A Quantitative Comparison of the Cardiac Ventricular Single Cell Models

Cardiac cell modelling provides a logical framework for integrating and understanding the results of experimental study of cardiac cellular physiology. Many computational models of cardiac ventricular cell have been developed to understand the work, out of these, three already existing models, namely Beeler-Reuter model, Luo-Rudy phase-I model and Luo-Rudy phase-II model is analyzed and their comparative study has been performed. These models are compared on the basis of action potential characteristics; peak overshoot potential, resting membrane potential, amplitude, notch potential, plateau potential, action potential duration and diastolic interval, at cycle length of 1000msec. These models are also analyzed one by one for action potential, transmembrane currents and calcium transients at different cycle lengths of 1000msec, 750msec, 500msec and 400msec. Our study reveals, when cycle length is decreased, wave shape of the action potential, all transmembrane currents (except INa) and intracellular calcium concentration becomes narrower for all the models. In LR-II model potassium time dependent current IK is approximately doubled as compared with the other two models, enhancing its ability to repolarize the membrane, so APD is smaller as compared with the other two models.