Designed Synthesis Of 2-(2,4-Dinitrophenyl)-8,8-Dimethyl-5-Phenyl-5,7,8,9-Tetrahydro-6H-[1,3,4] Thiadiazolo[2,3-B] Quinazolin-6-One Promoted by Zrocl2 |
Author(s): |
| Dr.N.Krishnarao , PRISM PG&DG College (Affiliated to Andhra University); V.Nagajyothi, PRISM PG&DG College (Affiliated to Andhra University) |
Keywords: |
| 5-(4-Nitrophenyl)-1, 3, 4-Thiadiazol-2-Amine, Dimedone, Aryl Aldehyde, ZrOCl2 Bioevluation |
Abstract |
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A simple and an efficient general procedure have been enhanced for the synthesis of 5-phenyl-5,7,8,9-tetrahydro-6H-[1,3,4] thiadiazolo[2,3-b]quinazolin-6-onefused analogous and biological properties. This analogous can be synthesized from compound (3) with dimedone and arylaldhyde in the presence of Lews acid catalyst (ZrOCl2) and the compound (3) can be prepared by the 2,4-dinitrobenzoic acid with thiosemicarbaide in the presence protic acid medium. All products have been characterized by 1H NMR and 13C NMR spectroscopy, and mass spectrometry. This method provides versatile advantages of organo-catalyst such as economical, nontoxic, highly stable, readily and easily available as well as solvent-free reaction conditions. |
Other Details |
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Paper ID: IJSRDV13I10034 Published in: Volume : 13, Issue : 1 Publication Date: 01/04/2025 Page(s): 126-129 |
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