Synthesis And Microbial Activity Of 4-(Indolyl)-6-Methyl-2-Thioxo-1, 2, 3, 4-Tetrahydropyrimidine-5-Carboxylate Analogous Exploring Silica Sulphuric Acid |
Author(s): |
| Dr N. Krishna Rao , PRISM PG & DG College (Affiliated to Andhra University); V.Varalakshmi, PRISM PG & DG College (Affiliated to Andhra University); Iswarya Lakshmi, PRISM PG & DG College (Affiliated to Andhra University) |
Keywords: |
| Acetylacetonate, Indole-3-Carbaldehydes, Silica Sulphuric Acid, Tetra Hydro Pyrimidines -2 -Thiones, Bioevluation |
Abstract |
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The present study, the synthesis of series a novel 4-(indol-3-yl)- 6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-yl) ethanone from the reaction of substituted indole -3-carbaldehydes (1.152 mmol), acetyl acetone (1mmol), thiourea(2 mmol) in the presence of two new catalyst Silica sulphuric acid at RT conditions. The analytical conformation newly synthesized compounds were evaluated by advanced spectroscopic data (1HNMR, 13C NMR & LCMS) and the structural determination was calculated by elemental analysis. In addition to the all newly synthesized compounds were evaluated by their microbial activity. |
Other Details |
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Paper ID: IJSRDV13I20056 Published in: Volume : 13, Issue : 2 Publication Date: 01/05/2025 Page(s): 55-58 |
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