Design, Synthesis and Biological Evaluation of a Novel Series of Oxazolines Promoted by ZnO as Catalyst |
Author(s): |
| Dr.N, Krishnarao , PRISM PG&DG College ; Teda Sai, PRISM PG&DG College ; P.Jangama Patrudu, PRISM PG&DG College ; Ch. Jyothi, PRISM PG&DG College |
Keywords: |
| Cinnamoylglycine, aromaticldehydes, ZnO, 4-((E)-benzylidene)-2-((E)-styryl) oxazol-5(4H)-one |
Abstract |
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The synthetic pathways and in-depth of synthesis and antimicrobial study a series of six 4-((E)-benzylidene)-2-((E)-styryl) oxazol-5(4H)-one (5) derivatives can be described. These moieties were prepared by condensation of substituted aromatic aldehydes (4) and cinnamoylglycine (3) with acetic anhydride in the presence ZnO as a catalyst. The compound (3) was prepared from cinnamoylchloride (2) with glycine and cinnamoylchloride (2) can be obtained from cinnamic acid and thionylchloride in the presence of MDC at 5-100C. All the six evaluated by advanced spectral data (1HNMR, 13CNMR & LCMS) and the structure of the all-titled derivatives can be estimated by elemental analysis. In addition to evaluation of ant-microbial properties against four bacterial strains as well as two fungal strains. |
Other Details |
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Paper ID: IJSRDV13I20076 Published in: Volume : 13, Issue : 2 Publication Date: 01/05/2025 Page(s): 71-76 |
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