Synthesis Of 2, 3-Disubstituted Quinazolinones- 4-(3H)-Ones Promoted by Inner Transition Metal Sulphate and Study of Antimicrobial Activity |
Author(s): |
| Dr.N.Krishnarao , PRISM PG & DG College (Affiliated to Andhra University); Dr. Shaik Lakshman, GSS, GITAM (Deemed to be University; B.V.Durgarao, ONGC ; Dr.K.Prathap, D. S. Government Degree College |
Keywords: |
| 2-Amino-N-Phenyl Benzamide, Substituted Aromatic Aldehyde, Ceric Ammonium Sulphate, 2,3-Disubstituted Quinazolin-4(3H)-Ones, Anti-Microbial Activity |
Abstract |
|
In this article is show the right path of the preparation of a series of 2, 3-di-substituted quinazolin-4-(3H)-ones analogous has been employed in a one pot by reacting 2-amino-N-phenyl benzamide with different substituted aromatic aldehydes in ethanol as a solvent promoted by CAS a Lewis acid catalyst and this procedure is straight forward and an effective synthesis. In addition to the analogous was evaluated by antibacterial activity and also the final analogous was analyzed by advanced spectroscopic data 1HNMR, 13CNMR, and mass. The advantaged of this approach was offers a greater number of benefits, including a high yield, a quick reaction time, mild reaction conditions, ease of operation, an easy work-up process that is ecofriendly benign, and the development of non-chromatographic methods for product purification. |
Other Details |
|
Paper ID: IJSRDV13I30038 Published in: Volume : 13, Issue : 3 Publication Date: 01/06/2025 Page(s): 57-60 |
Article Preview |
|
|
|
|
