Impact of Steam and Gamma Processing on Extractable |
Author(s): |
N. P. Shah , L. D. College of Engineering, Ahmedabad, Gujarat; N. M. Patel, L. D. College of Engineering, Ahmedabad, Gujarat; P. K. Patel, L. D. College of Engineering, Ahmedabad, Gujarat |
Keywords: |
Steam, Gamma, Extractable. |
Abstract |
In Pharma application various elastomeric components are used as primary packaging and fluid transportation. Several methods are available for sterilization and among all steam & gamma sterilization are most suitable methods for elastomeric components. In this study the effect of steam & gamma sterilization has been compared with non sterile components. Steam and gamma which has been used as a source for sterilization that may affect the molecular chain & crosslink density of elastomeric components. This study serves to help understand the potential deterioration of physical and chemical properties, the possible impact to functionality and the potential changes to the extractable/leachable profile as a result of sterilization. |
Other Details |
Paper ID: IJSRDV1I3031 Published in: Volume : 1, Issue : 3 Publication Date: 01/06/2013 Page(s): 527-528 |
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