Mathematical Model of P53 Gene in Gene Therapy Treatment for Lung Cancer |
Author(s): |
| N. Latha , KINGS COLLEGE OF ENGINEERING; Dr. G. Komahan, A.V.V.MSri Pushpam college(autonomous) |
Keywords: |
| Metabolism, Chromosomes, DNA, Apoptosis |
Abstract |
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The TP53 gene, which encodes p53, is one of the most frequently mutated genes in human cancers. It is reported that approximately half of all cancers have inactivated p53 [1]. The p53 protein has broad range of biological functions, including regulation of the cell cycle, apoptosis, senescence, DNA metabolism, angiogenesis, cellular differentiation, and the immune response. Gene therapy is the insertion of a functional gene into the cells of a patient to correct an inborn error of metabolism, to alter or repair an acquired genetic abnormality, and to provide a new function to a cell. Gene therapy for the treatment of cancer has a wide variety of potential uses. Gene therapy is an experimental treatment currently being tested in clinical trials that involves introducing additional genetic material (either DNA or RNA) into cells to fight cancer in a few different ways. |
Other Details |
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Paper ID: IJSRDV4I100195 Published in: Volume : 4, Issue : 10 Publication Date: 01/01/2017 Page(s): 267-270 |
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