Studies on Drug Releases of Anti-Inflammatory Tablets Containing Diclofenac Sodium Drug Releases Study

Oral release of drugs is the most preferable way of drug delivery due to the easiness of administration, patient compliance and flexibility in formulation. Where immediate release dosages may be broken down in gastric environment and affect the parts of gastric system. For avoid gastric troubles modified-release tablets include delayed release (eg. Enteric coated) and extended release (eg.sustained release) are designed to modify the rate, the place or the time at which the active ingredient are released. The experimental intend has conducted comparative study of different brands of six modified release type of marketed diclofenac sodium tablets in which Sustained release, enteric coating was taken. The study was completed by conducting different quality control parameters like identification, uniformity of weight variation, percentage assay, disintegration and dissolution on sustained release and enteric coated form of diclofenac sodium. All the tablets compared with authorized standard were found within the range. Dissolution studies showed that diclofenac sodium was slowly released in all samples of sustained release tablets compared to that of enteric coated tablets.