In Vivo Cytotoxicity and Genotoxicity Impact of Cypermethrin in Fresh Water Fish Channa Punctatus Bloch

Cypermethrin (polytrine-20E),a highly active and α-class II pyrethroid insecticide effective against a wide range of insects encountered in agriculture and animal husbandary.The cytogenetic effects of cypermethrin were evaluated using robust genotoxicity assay of chromosomal abarration (CA),mitotic index(MI),micronucleus test (MNT)of peripheral blood erythrocyte, sister chromatid exchanges (SCE) and proliferation Rate index (PRI) in kidney cells of channa punctuatus bloch fish exposed to cypermethrin(1,2.5 and 10 Mg/litre) for 5 days. 10 days, 15 day, 20 days and 25 days shows both concentration and period of dependent manner up to 20 days, than it reversed. Our study indicates fish exposed positivity genotoxic and cytotoxic due to the effect of the pesticide cypermethrin (ploytrene-20E) up to a certain concentration and period.MN, CA and SCE, and PRI and decreases index concentration dependent this decreases after 20 days and revised after the data available is statistically significant.