Antioxidant Evaluation and Synthesis of Novel Anhydrides from StobbeDicondensation: A Green Chemistry Approach

In present communication, one pot synthesis of acid esters (1) by Stobbedicondensation of alkylidene/ arylidene succinates with aldehydes or ketones and their subsequent hydrolysis to diacids (2), namely Fulgenic acids were reported. The Stobbedicondensation of various aromatic aldehydes or ketones with dimethyl succinate gives different types of cyclized products (3), namely (3E,4E)-3,4-dibenzylidenedihydrofuran-2,5-dione (3a), 3,4-bis (diphenyl methylene) dihydrofuran-2,5-dione(3b) ,(3Z, 4Z) 3, 4-bis ((4-chlorophenyl) (phenyl) (methylene) dihydrofuran-2, 5-dione (3c), (3E,4E)-3, 4-bis(1-phenylethylidene) dihydrofuran-2,5-dione (3d), (Z)-3-((4-chlorophenyl) (phenyl) methylene)-4-(diphenyl methylene)dihydrofuran-2,5-dione (3e),(3Z,4E)-3-((4-chlorophenyl) (phenyl) methylene) -4-(1-phenyl ethylidene) dihydrofuran-2, 5-dione (3f), (3Z, 4Z)-3, 4-bis (furan-2-ylmethylene) dihydrofuran-2, 5-dione (3g) and (3E, 4E)-3,4-di (butan-2-ylidene) dihydrofuran-2, 5-dione(3h) through green approach. The improved yields of Fulgenic acidsand its anhydrides (Fulgides) were observed by the green approach as compared with other classical methods employed so far.