A Reviewal Study on Pathogenesis of Disease Rheumatoid Arthritis(RA) |
Author(s): |
| Pooja Singh , Centre for Biotechnology and Microbiology Studies, A.P.S.University,Rewa(M.P.); Ugam Kumari Chauhan, Centre for Biotechnology and Microbiology Studies, A.P.S.University,Rewa(M.P.) |
Keywords: |
| T Lymphocytes, B Lymphocytes, Cardiovascular Risk, Rheumatoid Arthritis, Genetics |
Abstract |
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The aim of this review is to provide an overview of the new data emerged on the pathogenesis of RA Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic synovial inflammation leading to joint destruction and bone erosions. Although the pathogenic mechanisms underlying the disease are not fully elucidated, it is known that genetic susceptibility and environmental factors trigger an abnormal autoimmune response. Potentially, any organ and tissue could be affected by RA and the increased cardiovascular (CV) risk represents the major complication responsible for a worse prognosis. In this setting, the shared pathogenic mechanisms between RA pathogenesis and accelerated atherosclerosis further strengthen the rationale for a treat-to- target strategy with synthetic and bio- logic disease modifying anti-rheumatic drugs. |
Other Details |
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Paper ID: IJSRDV7I21317 Published in: Volume : 7, Issue : 2 Publication Date: 01/05/2019 Page(s): 1864-1872 |
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